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Monday, September 9, 2013

Plain Brown Cigarette Packs May Help Some Smokers Quit: Study

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After Australia mandated such packaging in 2012, most users found cigarettes 'less satisfying'MONDAY, July 22 (HealthDay News) -- Dulling down the look of cigarette packs may be another way to help dissuade smokers from their unhealthy habit, a new study shows.

When cigarettes come in plain brown packaging -- as they are now legally required to be sold in Australia -- most smokers said they thought more often about quitting as the cigarettes they smoked became "less satisfying."

"The use of plain packs with unbranded space [and] featuring larger health warnings as part of a comprehensive approach to tobacco control can help decrease tobacco use and its health consequences," said one U.S. expert, Patricia Folan, director of the Center for Tobacco Control at The North Shore-LIJ Health System in Great Neck, N.Y.

"Smokers who used the plain packs perceived their cigarettes to be of lower quality, rated quitting as a higher priority, and were more likely to report thoughts about quitting," said Folan, who was not involved in the new research.

In late 2012, Australia became the first and only country in the world to legislate plain brown packaging, accompanied by graphic health warnings that cover three-quarters of the front of the pack, for all tobacco products.

In order to assess the impact of the change, researchers interviewed 536 smokers shortly after the new law took effect and cigarettes with either plain packaging or branded packaging were available.

About 72 percent of the participants were buying the plain packs and nearly 28 percent were still buying branded packs with smaller health warnings.

There was little difference between the two groups in terms of how they viewed the health damage caused by smoking or how often they thought about those dangers, according to the study published online July 22 in BMJ Open.

However, compared to branded-pack smokers, those who bought the dowdier packs of cigarettes were 51 percent more likely to support the plain pack policy, 66 percent more likely to think their cigarettes were poorer quality than a year ago, and 70 percent more likely to find their cigarettes "less satisfying."

The plain pack smokers were also 81 percent more likely to have thought about quitting at least once a day during the previous week and to rate quitting as a higher priority in their lives, the researchers said.

That's important, the team wrote, because "frequency of thoughts about quitting has strong predictive validity in prospective studies for actually making a quit attempt."

In the United States, legal tussles over changes to cigarette packaging have made headlines over the past few years. In 2010, the U.S. Food and Drug Administration initially announced proposals for hard-hitting graphic imaging on tobacco products -- pictures of dying lung cancer patients, or diseased mouths and gums.

But those efforts have been stymied in the courts, with tobacco companies arguing that the mandated labeling violates free speech rights. In June, the FDA formally withdrew its 2010 proposals for tobacco product re-labeling.

Dr. Len Horovitz, a pulmonary specialist at Lenox Hill Hospital in New York City, believes plainer packaging may be one useful alternative strategy.

"It's not surprising to observe that packaging cigarettes less attractively might reduce cigarette consumption," he said. "Test marketing in the U.S. would be welcome."

And Folan said the Australian data might rekindle hope for tobacco product re-labeling in the United States.

"Hopefully, the data from this and other studies will provide sufficient and compelling evidence to the U.S. courts, which will permit the FDA to regulate tobacco product packaging by mandating the graphic warning labels," she said.

More information

The American Cancer Society offers a guide to quitting smoking.

SOURCES: Patricia Folan, R.N., director, Center for Tobacco Control, The North Shore-LIJ Health System, Great Neck, N.Y.; Len Horovitz, M.D., pulmonary specialist, Lenox Hill Hospital, New York City; BMJ Open, news release, July 22, 2013

Copyright c 2013 HealthDay. All rights reserved.


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Research Gets to Root of Redheads' Higher Melanoma Risk

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Gene mutation tied to ginger tresses may also play role in promoting cancer, mouse study suggestsTHURSDAY, Aug. 22 (HealthDay News) -- It's well known that natural redheads are at higher odds for deadly melanoma skin cancer, and new research in mice may help explain why.

Researchers at Harvard Medical School say the genetic mutation responsible for red hair and light skin also appears to promote a well-known cancer-causing pathway.

A person's hair color and skin tone are influenced by a gene receptor called melanocortin-1 (MC1R), and a mutation in MC1R accounts for the 1 percent to 2 percent of people who are born redheads.

In experiments with mice and cell cultures, researchers found that the same MC1R mutation -- called MC1R-RHC -- triggers a specific biochemical signaling pathway when a redhead is exposed to ultraviolet radiation from the sun and other sources.

This pathway, called P13K/Akt, has been tied to breast, ovarian and lung tumors, according to the study, which was published online Aug. 22 in the journal Molecular Cell.

"[The findings] provide a possible molecular mechanism as to why red-haired individuals harboring [these] mutations are much more susceptible to UV-induced skin damage than individuals with darker skin, resulting in a 10- to 100-fold higher frequency of melanoma," study co-senior author Wenyi Wei, an investigator at Beth Israel Deaconess Medical Center and an associate professor of pathology at Harvard, said in a medical center news release.

The researchers also said their findings are a starting point for future studies. For example, people who carry the MC1R mutation might be identified as being at higher skin cancer risk, or drugs that target the P13K/Akt pathway might help treat certain melanomas.

Melanoma is among the rarest of skin cancers, but it also is the most deadly, accounting for 75 percent of skin cancer deaths, the researchers said.

Researchers note that research conducted in animals often does not have the same results in humans.

More information

The U.S. National Cancer Institute has more about melanoma and other skin cancers.

SOURCE: Beth Israel Deaconess Medical Center, news release, Aug. 22, 2013

Copyright c 2013 HealthDay. All rights reserved.


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Melanoma May Return Years Later in Some

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But study also found those patients were less likely to die than those with early recurrenceFRIDAY, June 28 (HealthDay News) -- New research shows that melanoma can recur decades after initial treatment in roughly 9 percent of patients.

The findings show that people who have had melanoma require lifelong follow-up, the study authors said.

The investigators looked at over 4,700 melanoma patients and found that recurrence occurred in 408 patients who had been disease-free for 10 or more years. The recurrence rates were nearly 7 percent after 15 years and 11 percent after 25 years, according to the study in the July issue of the Journal of the American College of Surgeons.

But the researchers also found that patients whose melanoma recurred 10 or more years later were less likely to die than those whose melanoma recurred within three years of treatment. Those with late recurrence were about 40 percent less likely to die of melanoma than those with early recurrence, and those with late recurrence also had a better overall survival rate.

Patients whose melanoma did not come back until at least 10 years after treatment were younger on average than those with early recurrence (age 41 versus 51).

Also, patients with a later recurrence tended to have had an original melanoma with less dangerous characteristics, the researchers noted. They also found that men accounted for 66 percent of patients with early recurrence, compared with 57 percent of those with late recurrence.

"For patients with melanoma, survival beyond 10 years without a recurrence has been considered nearly synonymous with a cure," lead investigator Dr. Mark Faries, a professor of surgery at the John Wayne Cancer Institute at Saint John's Health Center in Santa Monica, Calif., said in a journal news release. "However, most studies do not follow-up patients longer than 10 years. Our study found that late melanoma recurrence is not rare and that it occurs more frequently in certain patient groups," he noted.

"It appears the risk of melanoma recurrence is never completely gone," Faries said. "One change that should result from our study is that people need to be followed-up for life with a physician after a diagnosis of melanoma," he pointed out.

"Fortunately, the vast majority of melanoma patients who remain disease-free longer than 10 years will not have a recurrence," Faries added. "However, patients should be aware that persistent or unexplained symptoms anywhere in the body might indicate a recurrence of their melanoma, and they should return to their physician to make sure the symptoms are not related."

Nearly 76,700 new cases of melanoma will be diagnosed in the United States this year, according to the American Cancer Society.

More information

The American Cancer Society has more about melanoma.

SOURCE: Journal of the American College of Surgeons, news release, June 27, 2013

Copyright c 2013 HealthDay. All rights reserved.


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Many Teen Girls Using Tanning Beds: Report

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Messages about skin cancer don't seem to outweigh the desire for a 'healthy glow'MONDAY, Aug. 19 (HealthDay News) -- Despite the risk of skin cancer, including deadly melanoma, nearly 30 percent of white female high school students use tanning beds and nearly 17 percent use them often, a new report finds.

Among white women aged 18 to 34, nearly 25 percent use tanning beds and 15 percent use them frequently, according to the U.S. Centers for Disease Control and Prevention.

"The high rates of indoor tanning among this population is very concerning," said report coauthor Gery Guy Jr., of the division of cancer prevention at the CDC.

Moreover, there have been no significant changes in the prevalence of indoor tanning in recent years, he said.

"Indoor tanning has been associated with skin cancer, particularly melanoma," Guy said. "The risk is increased among younger users and those who use it frequently."

Guy said young girls should be educated about the risks of ultraviolet ray exposure. Indoor tanning also should be restricted to adults, and claims about its benefits should be discredited, he said.

In addition, changing the perception that tanned skin is healthy and attractive would go a long way in reducing the use of tanning beds. "Tanned skin is damaged skin," he said.

The report was published online Aug. 19 in the journal JAMA Internal Medicine.

Dr. Melanie Palm, a spokeswomen for the Skin Cancer Foundation and director of Art of Skin MD in Solana Beach, Calif., said the study's finding are consistent with past research on the use of tanning beds.

More than 30 million Americans use tanning beds every year, Palm said. "There is a disproportionate number of girls and young women who use them," she said.

Although tanning is a known risk for skin cancer, there is a "cultural disconnect between the risk and the desire for a 'healthy glow,'" she said.

Parents need to be role models and educate their children about the dangers of UV exposure, Palm said. She said people should get into the habit of putting on sunscreen before going out, and girls and women who want a tanned look should use sunless tanning spray.

Cancer, however, is not the only risk of tanning. Exposure to UV rays ages the skin, making it less elastic, and causes wrinkles and spots, Palm said.

An industry spokesman, however, said the connection between indoor tanning and the risk for melanoma has not been confirmed.

"The body of studies on the relationship between UV exposure and melanoma skin cancer are replete with conflicting information," said John Overstreet, executive director of the Indoor Tanning Association.

"This study also ignores the many benefits of moderate exposure to ultraviolet light," he said. "With any human activity, there are risks and benefits, and the key is balance."

Another expert said many women weren't told about the dangers of tanning when they were teens.

"Most adult patients that I treat for skin cancers preface their discussion with me by saying that when they were teenagers they were never told that sunbathing or tanning was bad for them," said Dr. Jeffrey Salomon, an assistant clinical professor of plastic surgery at Yale University School of Medicine.

"If there was a way for teens to be able to talk to their future self, the remedy would be easy," he said. "But since the cancerous effects of tanning beds take time to evolve into skin cancers, it is hard for teens to personally identify with the risks. It is going to be a combination of parents, teachers and social media that will have to be used to target this audience."

More information

For more on indoor tanning, visit the U.S. Centers for Disease Control and Prevention.

SOURCES: Gery Guy Jr., Ph.D., M.P.H., division of cancer prevention and control, U.S. Centers for Disease Control and Prevention; Melanie Palm, M.D., spokeswomen, the Skin Cancer Foundation, director, Art of Skin MD, Solana Beach, Calif.; Jeffrey Salomon, M.D., assistant clinical professor, plastic surgery, Yale University School of Medicine, New Haven, Conn.; John Overstreet, executive director, Indoor Tanning Association, Washington, D.C.; Aug. 19, 2013, JAMA Internal Medicine, online

Copyright c 2013 HealthDay. All rights reserved.


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Smokers' Cell Damage Exists Even If Tests Miss It, Study Says

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Early changes look similar to abnormalities seen in lung cancer, researchers findWEDNESDAY, July 17 (HealthDay News) -- Even if medical tests are normal, smokers whose lungs appear healthy may still have damaged airway cells with characteristics similar to cells found in aggressive lung cancer, a new study indicates.

Researchers analyzed cells that line the airway from healthy nonsmokers and smokers with no detectable lung disease. The smokers' cells showed early signs of changes similar to those found in lung cancer.

"When you smoke a cigarette, some of the genetic programming of your lung cells is lost," senior investigator Dr. Ronald Crystal, chairman and professor of genetic medicine at Weill Cornell Medical College in New York City, said in a college news release.

"Your cells take on the appearance of a more primitive cell. It doesn't necessarily mean you will develop cancer, but that the soil is fertile to develop cancer," he explained.

The results of the study, published July 16 in the journal Stem Cell, show that smoking causes harm even when there is no clinical evidence that anything is wrong.

"The study doesn't say these people have cancer, but that the cells are already starting to lose control and become disordered," Crystal said. "The smoker thinks they are normal, and their doctor's exam is normal, but we know at the biologic level that all cigarette smokers' lungs are abnormal to some degree."

These very early changes can't be detected through physical examinations, lung function tests or X-rays. "The take-home message is: Don't smoke. Smoking is bad, and if you smoke, you're at risk," Crystal said.

Further research is needed to learn why smoking causes these changes. This could help scientists create treatments to prevent lung cancer.

More information

The U.S. National Cancer Institute has more about lung cancer prevention.

SOURCE: Weill Cornell Medical College, news release, July 16, 2013

Copyright c 2013 HealthDay. All rights reserved.


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Health Tip: Check for Skin Cancer

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(HealthDay News) -- Skin cancer is the most common type of cancer, but if caught early, it's often treatable. Performing a self-check can help identify any skin abnormalities quickly.

The Skin Cancer Foundation says you should look for these warning signs during a self-check:

Any changes or abnormalities in the skin that have grown larger and appear pearly, multicolored, translucent, tan, brown or black.Any moles, beauty marks, birthmarks or brown spots that change in texture, become thicker, grow larger, have an irregular border, appear after you're age 21, or are larger than a pencil eraser.Any area that continues to crust, bleed, erode or hurt.Any open wound that doesn't heal after three weeks.

Copyright c 2013 HealthDay. All rights reserved.


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Young Men Less Likely to Survive Melanoma Than Women: Study

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White males made up about 40 percent of deadly skin cancer patients, but more than 63 percent of deathsWEDNESDAY, June 26 (HealthDay News) -- White male teens and young adults are more likely to die of melanoma skin cancer than their female counterparts, a new study finds.

Researchers looked at data from more than 26,000 white patients, aged 15 to 39, in the United States who were diagnosed with melanoma between 1989 and 2009 and followed for an average of seven and a half years.

During the follow-up, there were nearly 1,600 melanoma-related deaths. Although males made up about 40 percent of the melanoma patients, they accounted for more than 63 percent of the deaths, according to the study, which was published June 26 in the journal JAMA Dermatology.

After adjusting for various factors, the investigators concluded that males were 55 percent more likely to die of melanoma than females.

Continued public health efforts are needed to raise young men's awareness of the dangers of melanoma, said Dr. Christina Gamba, of the Stanford University Medical Center, and colleagues.

"This alarming difference in the outcome highlights the urgent need for both behavioral interventions to promote early detection strategies in young men and further investigation of the biological basis for the sex disparity in melanoma survival," the study authors concluded.

Melanoma is the third most common type of cancer in American teens and young adults.

More information

The American Cancer Society has more about melanoma.

SOURCE: JAMA Dermatology, news release, June 26, 2013

Copyright c 2013 HealthDay. All rights reserved.


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New laser-based tool could dramatically improve the accuracy of brain tumor surgery

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AppId is over the quota

A new laser-based technology may make brain tumor surgery much more accurate, allowing surgeons to tell cancer tissue from normal brain at the microscopic level while they are operating, and avoid leaving behind cells that could spawn a new tumor. In a new paper, featured on the cover of the journal Science Translational Medicine, a team of scientists from the University of Michigan Medical School (home of the University of Michigan Comprehensive Cancer Center) and Harvard University (a component of the Dana-Farber Cancer Institute) researchers describes how the technique allows them to “see” the tiniest areas of tumor cells in brain tissue.

Click here to read full press release.?

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NCI comprehensive cancer centers logo

Among the research institutions NCI funds across the United States, it currently designates 68 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.


View the original article here

Study finds genomic differences in types of cervical cancer

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AppId is over the quota

A new study has revealed marked differences in the genomic terrain of the two most common types of cervical cancer, suggesting that patients might benefit from therapies geared to each type’s molecular idiosyncrasies. The study, published August 23, 2013 in the online version of the journal Cancer by researchers at Dana-Farber Cancer Institute and Brigham and Women’s Hospital (BWH), is the first to compare the spectrum of cancer-related gene mutations in the two main subtypes of cervical cancer – adenocarcinoma and squamous cell carcinoma.

Click here to read full press release.

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NCI comprehensive cancer centers logoAmong the research institutions NCI funds across the United States, it currently designates 68 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.


View the original article here

CA-125 change over time shows promise as screening tool for early detection of ovarian cancer

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AppId is over the quota

Evaluating its change over time, CA-125, the protein long-recognized for predicting ovarian cancer recurrence, now shows promise as a screening tool for early-stage disease, according to researchers at The University of Texas MD Anderson Cancer Center. The updated findings are published in Cancer; preliminary data were first presented at the 2010 American Society of Clinical Oncology (ASCO) annual meeting. If a larger study shows survival benefit, the simple blood test could offer a much-needed screening tool to detect ovarian cancer in its early stages – even in the most aggressive forms – in post-menopausal women at average risk for the disease.

Click here to read full press release.

###

NCI comprehensive cancer centers logoAmong the research institutions NCI funds across the United States, it currently designates 68 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.


View the original article here