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Showing posts with label Process. Show all posts
Showing posts with label Process. Show all posts

Monday, December 23, 2013

‘Biggest Loser' trainer says fitness a mental and physical process

By Dorene Internicola

NEW YORK (Reuters) - As celebrity trainer Dolvett Quince challenges and prods obese, unfit contestants to slim down and shape up on the weight-loss TV show "The Biggest Loser" he also uses survivor skills acquired during his childhood to boost their self esteem.

The Los Angeles-based trainer said getting fit is a mental as well as a physical challenge. He can identify with the struggles of his outsized team because as an adopted child he was mentally and physically abused and has experienced his share of self doubt.

"I walked into an environment where education was low and discipline was high," said Quince, 40, who was born in Stamford, Connecticut. "I understand what it's like to feel defeated and because I faced my own demons I can empower others."

Quince said fitness for people who are 100 pounds (45kg) or more overweight, involves a lot more than pushups.

"Health is a four-point component: emotional, physical spiritual and mental," said Quince, whose best-selling book, "The 3-1-2-1 Diet: Eat and Cheat Your Way to Weight Loss - Up to 10 Pounds in 21 Days," was published last month.

The fitness coach, who began his career at the YMCA where his clients included the elderly, mothers, teenagers and children, tries to chip away at people's personal doubts and past disappointments.

"People become extremely vulnerable as their bodies fatigue and they're going through transformations. It's in that vulnerability that the concrete cracks and some light pushes in," he said in a phone interview.

Karate, yoga, hiking and basketball are included in his fitness regime. At the gym he suggests combining cardio training, usually running on a treadmill, with strength training to systematically target different muscle groups.

"Doing intervals keeps your body guessing," he explained.

Lauve Metcalfe, a wellness coach and past president of the International Association for Worksite Health Promotion, believes shows like "The Biggest Loser" can raise public awareness about the importance of fitness.

But she has concerns about the rapid weight loss, often 10 pounds a week or more, expected of contestants.

"A pound and a half per week is a healthier goal," said Metcalfe, who is based in Tucson, Arizona. "And the aspect of every week getting on that scale, and the shame if you haven't met (the goal), is a negative,"

Quince attributes his success in helping people get in shape to his refusal to take no for an answer.

"I think people don't necessarily truly love working out," he said. "I think it's more like, ‘Man, must we work out? Can't we just have a drink?"

His job, he added, is to instill belief as well as to motivate people to move.

(Editing by Andrew Hay)


View the original article here

Wednesday, September 25, 2013

Cancer-killing cells controlled by epigenetic process

Sep. 23, 2013 — Natural killer (NK) cells in the human body can kill and contain viruses and cancerous tumors, and a new study from the University of Southern California (USC) describes for the first time how those cells can be manipulated by epigenetics. The discovery, detailed in the Proceedings of the National Academy of Sciences, paves the way for developing more effective cancer drugs.

"Natural killer cells are very attractive targets for immunotherapy because they are able to kill tumor cells," said Si-Yi Chen, M.D., Ph.D., a faculty member of the USC Norris Comprehensive Cancer Center and senior author of the study. "While scientists all around the world are working on developing new drugs using NK cells, none of the drugs in development focuses on epigenetic regulation of the cells. Our study describes how an epigenetic process involving the enzyme MYSM1 plays a critical role in the development of natural killer cells."

Epigenetics involve biochemical changes in the body that directly affect DNA, turning some genes on and turning others off. MYSM1 is an enzyme in the body's immune system that turns genes on and off by modifying proteins called histones embedded in DNA.

Through a series of experiments in mice, Chen and his colleagues demonstrate that MYSM1 is required for natural killer cells to mature and function properly.

"We found that MYSM1 creates access to proteins that enhance gene transcription and, ultimately, the maturation of natural killer cells themselves," said Vijayalakshmi Nandakumar, a Ph.D. student at the Keck School of Medicine of USC and the study's first author. "To date, there are no elaborate reports linking an epigenetic phenomenon to natural killer cell development. More importantly, unlike conventional therapies, NK cell-based therapies have shown to be more effective against metastasis. We believe cancer drugs targeting this pathway could be a viable option for future immunotherapies."

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Story Source:

The above story is based on materials provided by University of Southern California - Health Sciences, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. V. Nandakumar, Y. Chou, L. Zang, X. F. Huang, S.-Y. Chen. Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1308888110

Note: If no author is given, the source is cited instead.


View the original article here