Biocon to start selling breast cancer drug in India in February

MUMBAI (Reuters) - Biocon Ltd said its generic version of Roche's Herceptin breast cancer treatment would be available to patients in India from the first week of February.

Bangalore-based Biocon jointly developed biosimilar trastuzumab, which received the Indian drug regulator's marketing approval in November, with U.S.-based Mylan Inc.

About 150,000 people are diagnosed with breast cancer every year in India, of which 25 percent are eligible for treatment with trastuzumab, Biocon said.

Roche decided not to pursue a patent application for its breast cancer drug Herceptin in India, paving the way for generic drugmakers to produce cheaper copies, known as biosimilars because they are not identical to the original drug.

Global sales for Herceptin were valued at about $6.4 billion in 2012, including about $21 million in India, Biocon said.

(Reporting by Aradhana Aravindan; Editing by Sonya Hepinstall)

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Tapping a valuable resource or invading the environment? Research examines the start of fracking in Ohio

Sep. 25, 2013 — A new study is examining methane and other components in groundwater wells, in advance of drilling for shale gas that's expected over the next several years in an Ohio region.

Amy Townsend-Small, a University of Cincinnati assistant professor of geology, will present on the study on Sept. 27, at the 10th Applied Isotope Geochemistry Conference in Budapest, Hungary.

The team of UC researchers spent a year doing periodic testing of groundwater wells in Carroll County, Ohio, a section of Ohio that sits along the shale-rich Pennsylvania-West Virginia borders. The study analyzed 25 groundwater wells at varying distances from proposed fracking sites in the rural, Appalachian, Utica Shale region of Carroll County. Because the region is so rural, the majority of the population relies on groundwater wells for their water supply.

"This is a major area for shale gas drilling in Ohio, and one reason is because shales in the area are thought to have a good amount of liquid fuel as well as natural gas," says Townsend-Small.

The researchers are currently analyzing samples from groundwater wells over a one-year period, with water samples drawn every three-to-four months.

The samples are being analyzed for concentrations of methane as well as hydrocarbons -- a carcinogenic compound -- and salt, which is pulled up in the fracking water mixture from the shales, which are actually ancient ocean sediments.

"We're examining changes over time resulting from fracking, and since this is just beginning in Ohio, we have the opportunity to make some baseline assessments," says Townsend-Small.

Hydraulic fracturing, or fracking, involves using millions of gallons of water mixed with sand and chemicals to break up organic-rich shale to release natural gas resources. Proponents say fracking promises a future in lower energy prices, cleaner energy and additional jobs amid a frail economy. Opponents raise concerns about the practice leading to increased methane gas levels (known as the greenhouse gas) and other contamination -- resulting from spillover of fracking wastewater -- of groundwater in shale-rich regions.

Townsend-Small explains that some groundwater wells naturally hold a certain level of methane due to the decomposition of organic matter. It's not toxic in drinking water, but high levels can result in explosion. The study includes measurements of stable isotopes, which can indicate whether methane is derived from natural organic matter decomposition or from fossil fuels.

Other chemicals in fracking wastewater are toxic and dangerous for drinking water. Future UC research includes measurements of some of these compounds, as fracking progresses in the region.

The U.S. Energy Information Administration reported this summer that natural gas reserve additions in 2011 ranked as the second-largest annual increase since 1977, with hydraulic fracturing adding to increased oil and gas reserves.

The Ohio Department of Natural Resources reports that 882 sites in the state of Ohio have been awarded permits for fracking. In Carroll County, 327 sites have been awarded permits and 236 have been drilled.

Funding for the UC study was supported in coordination with UC Foundation by a $20,000 grant from the Missouri-based Deer Park Foundation, a $2,500 grant from the Cincinnati-based David and Sara Weston Foundation and an $85,714 grant from the Ohio Board of Regents.

Townsend-Small and her colleagues in the UC Department of Geology were also awarded a $400,000, 3-year grant from the National Science Foundation (EAR-1229114) for an isotope ratio mass spectrometer. The instrument measures the stable isotope composition of methane, which can indicate whether it is derived from biological activity or natural gas.

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Humanitarian emergencies, an opportunity for fresh start in providing sustainable, long-term mental health services

16 August 2013 | Geneva - Humanitarian agencies work hard to help people with their mental health and psychosocial needs in the aftermath of emergencies, but too often opportunities are missed to strengthen mental health systems for the long-term, according to a new World Health Organization (WHO) report, "Building back better: Sustainable mental health care after emergencies" released for World Humanitarian Day (August 19).

“In spite of their tragic nature, emergency situations are opportunities to improve the lives of large numbers of people through improving mental health services,” says Dr Bruce Aylward, WHO’s Assistant Director-General overseeing the Organization’s work in humanitarian emergencies. "We can do better for emergency-affected populations by working with the government on sustainable mental health care from the outset.”

The report provides guidance for strengthening mental health systems after emergencies and examples from Afghanistan, Burundi, Indonesia (Aceh Province), Iraq, Jordan, Kosovo, Somalia, Sri Lanka, Timor-Leste, and West Bank and Gaza Strip.

Contributors from each area report not only their major achievements, but also their most difficult challenges and how they were overcome. Key overlapping practices emerging from these experiences are summarized.

Findings from the report include:

• Indonesia (Aceh): Like many provinces in Indonesia, Aceh had only institution-based care before the tsunami of 2004. Today, most districts have primary mental health services supported by secondary care at district general hospitals.
• Iraq: Since 2004, significant progress has been made toward the creation of a comprehensive mental health system. More than 50% of general practitioners have received mental health training.
• Kosovo: Starting from a hospital-based model of care in 1999 after the conflict, a system of community-based mental health care is now available.
• Sri Lanka: Since the 2004 tsunami, a new national mental health policy has guided reform, which now extends to most parts of the country. Several new cadres of community-based mental health workers have been developed.
• Timor-Leste: Building from a complete absence of mental health services in 1999, the country today has a comprehensive community-based mental health system.

The possibilities presented by emergency situations are significant because major gaps remain worldwide in the realization of comprehensive, community-based mental health care.

“The current situation is alarming,” says Dr Shekhar Saxena, WHO Director for Mental Health. “Health systems have not yet adequately responded to the burden of mental disorders. We know that the vast majority of people with severe mental disorders receive no treatment whatsoever in low-income and middle-income countries.”

Transforming the mental health care systems in turn would improve the well-being, functioning, and resilience of individuals, societies, and countries recovering from emergencies, the report notes.

By releasing this report, WHO aims to help guide policymakers to reform their mental health systems, especially those which may be susceptible to future emergencies. Already in 2013, the world has witnessed numerous emergency situations, from the crisis in Syria and neighbouring countries to heavy fighting in Mali and the Central African Republic, major flooding in parts of the Americas, Africa, and Asia, and others.

For more information please contact:

Tarik Jasarevic
WHO Communications Officer
Telephone: +41 22 791 5099
Mobile: +41 793 676 214
E-mail: jasarevict@who.int

View the original article here

Humanitarian emergencies, an opportunity for fresh start in providing sustainable, long-term mental health services

16 August 2013 | Geneva - Humanitarian agencies work hard to help people with their mental health and psychosocial needs in the aftermath of emergencies, but too often opportunities are missed to strengthen mental health systems for the long-term, according to a new World Health Organization (WHO) report, "Building back better: Sustainable mental health care after emergencies" released for World Humanitarian Day (August 19).

“In spite of their tragic nature, emergency situations are opportunities to improve the lives of large numbers of people through improving mental health services,” says Dr Bruce Aylward, WHO’s Assistant Director-General overseeing the Organization’s work in humanitarian emergencies. "We can do better for emergency-affected populations by working with the government on sustainable mental health care from the outset.”

The report provides guidance for strengthening mental health systems after emergencies and examples from Afghanistan, Burundi, Indonesia (Aceh Province), Iraq, Jordan, Kosovo, Somalia, Sri Lanka, Timor-Leste, and West Bank and Gaza Strip.

Contributors from each area report not only their major achievements, but also their most difficult challenges and how they were overcome. Key overlapping practices emerging from these experiences are summarized.

Indonesia (Aceh): Like many provinces in Indonesia, Aceh had only institution-based care before the tsunami of 2004. Today, most districts have primary mental health services supported by secondary care at district general hospitals.Iraq: Since 2004, significant progress has been made toward the creation of a comprehensive mental health system. More than 50% of general practitioners have received mental health training.Kosovo: Starting from a hospital-based model of care in 1999 after the conflict, a system of community-based mental health care is now available. Sri Lanka: Since the 2004 tsunami, a new national mental health policy has guided reform, which now extends to most parts of the country. Several new cadres of community-based mental health workers have been developed. Timor-Leste: Building from a complete absence of mental health services in 1999, the country today has a comprehensive community-based mental health system.

The possibilities presented by emergency situations are significant because major gaps remain worldwide in the realization of comprehensive, community-based mental health care.

“The current situation is alarming,” says Dr Shekhar Saxena, WHO Director for Mental Health. “Health systems have not yet adequately responded to the burden of mental disorders. We know that the vast majority of people with severe mental disorders receive no treatment whatsoever in low-income and middle-income countries.”

Transforming the mental health care systems in turn would improve the well-being, functioning, and resilience of individuals, societies, and countries recovering from emergencies, the report notes.

By releasing this report, WHO aims to help guide policymakers to reform their mental health systems, especially those which may be susceptible to future emergencies. Already in 2013, the world has witnessed numerous emergency situations, from the crisis in Syria and neighbouring countries to heavy fighting in Mali and the Central African Republic, major flooding in parts of the Americas, Africa, and Asia, and others.

Tarik Jasarevic
WHO Communications Officer
Telephone: +41 22 791 5099
Mobile: +41 793 676 214
E-mail: jasarevict@who.int

View the original article here