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Showing posts with label active. Show all posts
Showing posts with label active. Show all posts

Tuesday, April 8, 2014

'Glue' holding together skin cells, other epithelial tissue more active than realized

The strong mechanical attachments -- the "glue" -- that hold together the cells of the skin and the other epithelial tissues of the body are the adherens junctions.

These junctions are responsible for maintaining the shape and integrity of the sheets of epithelial cells that line such body cavities as the digestive tract, as well as the surfaces of structures such as the heart. Defects in the proteins of these attachments have been implicated as potential contributors to the development and spread of cancer.

Recent research on Drosophila flies, combined with previous studies in cell cultures, are challenging the traditional view that adherens junctions maintain tissue integrity by passively resisting disruptive forces.

In studies with Drosophila embryos, the Princeton University lab of Nobel laureate Eric Wieschaus, Ph.D., has uncovered the first evidence in living organisms that adherens junctions actively respond to mechanical cues by remodeling their own position and intensity, which in turn restructures the cells.

Mo Weng, Ph.D., postdoctoral fellow in the lab, used live imaging and quantitative image analysis of fixed and live embryos to determine that these changes depend on mechanical force mediated by the motor protein myosin and precede the changes in the distribution of cell polarity proteins, such as Bazooka, that are responsible for spatial organization of the cells.

Understanding the regulation and functioning of adherens junctions sheds light on the organization of multi-cellularity -- from cell-cell contacts to the remodeling of tissues and organs during life.

Story Source:

The above story is based on materials provided by Genetics Society of America. Note: Materials may be edited for content and length.


View the original article here

Wednesday, November 13, 2013

Thin, active invisibility cloak demonstrated for first time

Nov. 12, 2013 — Invisibility cloaking is no longer the stuff of science fiction: two researchers in The Edward S. Rogers Sr. Department of Electrical & Computer Engineering have demonstrated an effective invisibility cloak that is thin, scalable and adaptive to different types and sizes of objects.

Professor George Eleftheriades and PhD student Michael Selvanayagam have designed and tested a new approach to cloaking -- by surrounding an object with small antennas that collectively radiate an electromagnetic field. The radiated field cancels out any waves scattering off the cloaked object. Their paper 'Experimental demonstration of active electromagnetic cloaking' appears today in the journal Physical Review X.

"We've taken an electrical engineering approach, but that's what we are excited about," says Eleftheriades. "It's very practical."

Picture a mailbox sitting on the street. When light hits the mailbox and bounces back into your eyes, you see the mailbox. When radio waves hit the mailbox and bounce back to your radar detector, you detect the mailbox. Eleftheriades and Selvanyagam's system wraps the mailbox in a layer of tiny antennas that radiate a field away from the box, cancelling out any waves that would bounce back. In this way, the mailbox becomes undetectable to radar.

"We've demonstrated a different way of doing it," says Eleftheriades. "It's very simple: instead of surrounding what you're trying to cloak with a thick metamaterial shell, we surround it with one layer of tiny antennas, and this layer radiates back a field that cancels the reflections from the object."

Their experimental demonstration effectively cloaked a metal cylinder from radio waves using one layer of loop antennas. The system can be scaled up to cloak larger objects using more loops, and Eleftheriades says the loops could become printed and flat, like a blanket or skin. Currently the antenna loops must be manually attuned to the electromagnetic frequency they need to cancel, but in future they could function both as sensors and active antennas, adjusting to different waves in real time, much like the technology behind noise-cancelling headphones.

Work on developing a functional invisibility cloak began around 2006, but early systems were necessarily large and clunky -- if you wanted to cloak a car, for example, in practice you would have to completely envelop the vehicle in many layers of metamaterials in order to effectively "shield" it from electromagnetic radiation. The sheer size and inflexibility of the approach makes it impractical for real-world uses. Earlier attempts to make thin cloaks were not adaptive and active, and could work only for specific small objects.

Beyond obvious applications, such as hiding military vehicles or conducting surveillance operations, this cloaking technology could eliminate obstacles -- for example, structures interrupting signals from cellular base stations could be cloaked to allow signals to pass by freely. The system can also alter the signature of a cloaked object, making it appear bigger, smaller, or even shifting it in space. And though their tests showed the cloaking system works with radio waves, re-tuning it to work with Terahertz (T-rays) or light waves could use the same principle as the necessary antenna technology matures.

"There are more applications for radio than for light," says Eleftheriades. "It's just a matter of technology -- you can use the same principle for light, and the corresponding antenna technology is a very hot area of research."


View the original article here