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Showing posts with label online. Show all posts
Showing posts with label online. Show all posts

Tuesday, January 7, 2014

Online colorectal cancer risk calculator

Jan. 3, 2014 — Researchers at Cleveland Clinic have developed a new tool called CRC-PRO that allows physicians to quickly and accurately predict an individual's risk of colorectal cancer, as published in the current edition of the Journal of the American Board of Family Medicine.

CRC-PRO, or Colorectal Cancer Predicted Risk Online, is designed to help both patients and physicians determine when screening for colorectal cancer is appropriate. Current guidelines recommend patients are screened at the age of 50. However, with this new tool, physicians will be better able to identify who is truly at risk and when screenings for patients are necessary.

To develop the calculator, the researchers -- led by Brian Wells, M.D., Ph.D., of the Department of Quantitative Health Sciences in Cleveland Clinic's Lerner Research Institute -- analyzed data on over 180,000 patients from a longitudinal study conducted at the University of Hawaii. Patients were followed for up to 11.5 years to determine which factors were highly associated with the development of colorectal cancer.

"Creating a risk calculator that includes multiple risk factors offers clinicians a means to more accurately predict risk than the simple age-based cutoffs currently used in clinical practice," said Dr. Wells. "Clinicians could decide to screen high-risk patients earlier than age 50, while delaying or foregoing screening in low-risk individuals. "

Wells and his colleagues hope that their new, user-friendly calculator will help improve the efficiency of colorectal cancer screenings. They also believe prediction tools like this can help lower healthcare costs by cutting down on unnecessary testing.

The Multiethnic Cohort Study comprised a diverse ethnic population. Previously, most research in this area has been performed predominately in Caucasians. Because cancer risk differs drastically in different racial groups, the researchers felt that an ethnically diverse population would more accurately reflect true cancer risk.

"The development of risk prediction calculators like the CRC-PRO is vital for improving medical decision-making," said Michael Kattan, Ph.D., Chair of the Department of Quantitative Health Sciences in Cleveland Clinic's Lerner Research Institute. "Tools like this represent another step toward personalized medicine that will ultimately improve efficiency, outcomes and patient care."

Kattan and his research team are involved in the creation of numerous risk prediction tools, including heart disease and cancers of the breast, prostate and thyroid, that are available at http://rcalc.ccf.org. He is currently working on software that will integrate these tools for automatic calculation in the Electronic Health Record to make this process easier for physicians.


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Saturday, September 28, 2013

Race to get Obamacare online sites running goes to the wire

By Sharon Begley

NEW YORK (Reuters) - Just days before the launch of the new U.S. state health insurance exchanges that are the centerpiece of the Affordable Care Act, a nationwide push is still under way to test and patch the technology behind the online sites.

Officials working on the sites have acknowledged that information technology (IT) failures will prevent many of them from functioning fully for weeks, and perhaps longer. That will slow the government's drive to enroll millions of uninsured Americans under President Barack Obama's healthcare reform law starting Tuesday.

From a political standpoint, a successful opening day will shape perceptions of Obama's signature policy initiative. But the system's functioning is to a large extent beyond the control of politicians and policy experts, and instead sits in the hands of the battalions of coders working for IT sub-contractors.

Six months ago, people involved in setting up the exchanges were more hopeful that everything would be ready on time, said Cristine Vogel, an associate director at Navigant Consulting.

"I don't think there were enough hours in the day, or enough people with the skills," she said. "When we look back, I think we'll see that we missed an opportunity to share technology."

Opponents of the healthcare reform known as Obamacare say the computer problems bolster their view that the 2010 law is a "train wreck" and should be delayed or repealed. The Obama administration insists the exchanges will be open for business on October 1, even if some uninsured Americans may not be able to buy coverage right away. More importantly, they say, the new health plans will begin to provide health coverage on January 1, as planned.

"So long as the website is accessible and the plans and the plan information are displayed properly so a consumer can shop for coverage and compare the plans, they will claim victory," said Chris C1ondeluci, an employee benefits attorney at Venable LLP and a former staffer at the Senate Finance Committee who helped draft the Affordable Care Act.

FIRST-DAY CRASH?

This week, the Obama administration said its Spanish-language website would not be ready in time, and that it would be weeks before small businesses and their employees could sign up online for coverage on exchanges operated by the federal government.

The exchanges in Colorado and the District of Columbia, meanwhile, cannot calculate the amount of federal subsidies customers qualify for.

In New York, the exchange is not able to transfer data to some insurers instantaneously, as planned, one carrier told Reuters. Instead, the data will be sent in batches once a day or so. The glitch will not affect customers, but it raises questions that New York might have other IT problems.

Oregon had sufficient qualms about its online insurance marketplace that no one can enroll unless they use a trained, certified agent or other "community partner."

As late as this week, Oregon also had trouble correctly displaying information about insurance plans on a test site. The problem could mislead customers about deductibles, prices and other details if it occurs on the live site Tuesday.

In Ohio, Lieutenant Governor Mary Taylor, a fierce opponent of the healthcare law, said in a radio interview this week that her state's online exchange, which is being run by the federal government, could well crash on its first day.

In testing, she said, some plans filed by insurers "sat in a queue for the federal government for a week, so my concern is something similar is going to happen on October 1 because of the amount of (online) traffic."

WORKAROUNDS OFFERED, TAKE TIME

In most cases, exchanges will offer workarounds that will take time to execute. In Washington, D.C., off-line contractors will calculate federal subsidies and inform applicants what they qualify for in November, by which time the online calculator might be working.

In Colorado, until at least November, customers will have to call phone service centers, where representatives will manually take them through the calculations to determine what subsidies they qualify for.

Even before the exchanges open, the finger-pointing has begun, with states blaming contractors for glitches and contractors blaming states or other contractors.

The system to calculate federal subsidies for the D.C. exchange was built by Curam Software, which IBM acquired in 2011. In tests of complex family situations, the software was getting subsidies wrong 15 percent of the time, said exchange spokesman Richard Sorian.

In a statement, IBM spokesman Mitchell Derman said the city "decided that a phased-in approach best meets the needs of its citizens." He pointed out that Curam also built the eligibility software in Maryland and Minnesota, "two states that plan to have full functionality on October 1."

In other words, a company that achieved its goal on time in two states fell short in a third. The reasons, said outside experts, include relationships among contractors and the specifics of existing computer systems in a state.

In Washington, Infosys, the giant Bangalore, India,-based technology company, is the system integrator - the contractor that takes software from sub-contractors like Curam and puts it all together. The fact that Curam's calculation software is working on other exchanges suggests the glitch may not lie in its integration with the D.C. exchange's other IT.

"A software package like Curam's is put into the system by the system implementer, not the software provider," said an IT expert not involved in the D.C. exchange. A spokesman for Infosys was not able to comment on its D.C. work.

MEDICAID SYSTEMS POSE HUGE HURDLE

One of the most difficult IT jobs has been to integrate each health insurance exchange with its state Medicaid system. These legacy systems are typically decades old. In Massachusetts, for instance, the system runs on the COBOL programming language, which is to today's languages like a rotary phone is to an iPhone-5.

"These legacy systems are old and difficult to configure and re-configure," said Tom Dehner, managing principal at Health Management Associates, a healthcare consultant, in Boston and former director of Massachusetts Medicaid.

"To change how eligibility is calculated," as federal law now requires, he said, "you need to modify your Medicaid system, and that's not something you can do by buying software off the shelf."

The difficulty of interfacing with Medicaid will keep Colorado's exchange from calculating subsidies online.

To determine eligibility for federal subsidies, explained Nathan Wilkes, a member of the board of Connect for Health Colorado, the system "first goes through Medicaid determination. That means connecting to a legacy system," he said.

"Six or nine months ago we got an early warning that the way we wanted to integrate these systems wouldn't work, and then time got away from us."

Colorado's exchange tested 100,000 scenarios to see how its software calculated subsidies, and got error after error.

"It's an IT nightmare," Wilkes said.

(Additional reporting by Lewis Krauskopf and Caroline Humer; Editing by Michele Gershberg and Doina Chiacu)


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Sunday, July 1, 2012

Fake ADHD drug Adderall sold online, U.S. FDA warns

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AppId is over the quota

WASHINGTON (Reuters) - Some websites are peddling fake versions of Adderall, a treatment for attention deficit hyperactivity disorder that is currently in short supply in the United States, federal regulators warned.

The U.S. Food and Drug Administration on Tuesday said it has learned of at least two cases in which people received counterfeit versions of the 30-milligram dose of the drug with the wrong active ingredients -- ones that treat acute pain, not attention problems. The fake pill is ineffective and may be harmful, the FDA said.

The popular stimulant, made by Teva Pharmaceutical Industries and others, has been in shortage since at least last year, which may make it a target for rogue websites and distributors, the FDA said.

"Consumers should be extra cautious when buying their medicines from online sources," the FDA said in a statement.

Teva informed the FDA about the counterfeit pills after learning of the problem from people who bought the drug online. The FDA said it is uncertain how many people in total may have received counterfeit medicine, or which websites were involved.

Teva, when asked for comment, said it found out about the counterfeit Adderall from a consumer who noticed misspellings on the packaging.

Adderall is made from a controlled substance, meaning it is addictive and has the potential to be abused. The Drug Enforcement Administration tightly regulates how much of the drug's active pharmaceutical ingredient can be distributed to manufacturers each year in order to prevent diversion of the drug for inappropriate uses -- such as by students who want to increase focus to improve test scores.

The DEA authorizes a certain amount of Adderall's active ingredients - mixed amphetamine salts - to be released to drugmakers each year. But companies are saying that amount may not be enough to meet soaring demand for the drug.

In 2010, more than 18 million prescriptions were written for Adderall, up 13.4 percent from 2009, according to IMS Health. ADHD is one of the most common childhood disorders, with an average of 9 percent of children between the ages of five and 17 diagnosed with it each year, according to the Centers for Disease Control and Prevention.

The FDA said Adderall is in short supply because of problems getting active ingredients to make the drug.

Adderall is made in several doses and formulations, but it is the shorter-acting, instant release forms of the drug that are in shortest supply. These are made by Teva, as well as CorePharma LLC and Sandoz, a unit of Swiss drugmaker Novartis AG.

Normally, the drug has four active ingredients: dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate. But the FDA's tests found the counterfeit versions of Adderall had only two ingredients - tramadol and acetaminophen, often used to treat pain.

The fake pills often have misspellings on the packages, and are white and unmarked. Teva's real version of the pill is orange or peach-colored, and embossed with "dp" on one side and "30" on the other. The fake Adderall also comes in foil packages, instead of the bottles that Teva uses.

(Reporting by Anna Yukhananov; Ediing by Steve Orlofsky)