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Showing posts with label switch. Show all posts
Showing posts with label switch. Show all posts

Sunday, September 22, 2013

Researchers identify switch that controls growth of most aggressive brain tumor cells

Sep. 20, 2013 — Researchers at UT Southwestern Medical Center have identified a cellular switch that potentially can be turned off and on to slow down, and eventually inhibit the growth of the most commonly diagnosed and aggressive malignant brain tumor.

Findings of their investigation show that the protein RIP1 acts as a mediator of brain tumor cell survival, either protecting or destroying cells. Researchers believe that the protein, found in most glioblastomas, can be targeted to develop a drug treatment for these highly malignant brain tumors. The study was published online Aug. 22 in Cell Reports.

"Our study identifies a new mechanism involving RIP1that regulates cell division and death in glioblastomas," said senior author Dr. Amyn Habib, associate professor of neurology and neurotherapeutics at UT Southwestern, and staff neurologist at VA North Texas Health Care System. "For individuals with glioblastomas, this finding identified a target for the development of a drug treatment option that currently does not exist."

In the study, researchers used animal models to examine the interactions of the cell receptor EGFRvIII and RIP1. Both are used to activate NFκB, a family of proteins that is important to the growth of cancerous tumor cells. When RIP1 is switched off in the experimental model, NFκB and the signaling that promotes tumor growth is also inhibited. Furthermore, the findings show that RIP1 can be activated to divert cancer cells into a death mode so that they self-destruct.

According to the American Cancer Society, about 30 percent of brain tumors are gliomas, a fast-growing, treatment-resistant type of tumor that includes glioblastomas, astrocytomas, oligodendrogliomas, and ependymomas. In many cases, survival is tied to novel clinical trial treatments and research that will lead to drug development.


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Sunday, September 15, 2013

Japan to switch off nuclear power, may be some time before it's on again

By Osamu Tsukimori

TOKYO (Reuters) - Japan is set to be nuclear power-free, for just the third time in more than four decades, and with no firm date for re-starting an energy source that has provided about 30 percent of electricity to the world's third-largest economy.

Kansai Electric Power Co's 1,180 MW Ohi No.4 reactor is scheduled to be disconnected from the power grid late on Sunday and then shut for planned maintenance. It is the only one of Japan's 50 reactors in operation after the nuclear industry came to a virtual halt following the March 2011 Fukushima disaster.

Japan last went without nuclear power in May-June 2012 - the first shutdown since 1970 - a year after a massive earthquake and tsunami triggered reactor meltdowns and radiation leaks at the Fukushima facility. The country's nuclear reactors provided close to a third of the electricity to keep the $5 trillion economy going before the Fukushima disaster, and utilities have had to spend billions of dollars importing oil, gas and coal to make up for the shortfall.

In 2011, Japan suffered its first trade deficit in more than three decades, and in July of this year it logged its third-biggest trade deficit on record, at 1.02 trillion yen ($10.5 billion), as a weak yen and rising oil prices made energy imports more expensive.

Several nuclear operators applied in July to re-start reactors under new rules drawn up following the Fukushima disaster, but approvals are likely to be tough to get as the industry regulator strives to show a skeptical public it is serious about safety.

Industry projections for a re-start vary from as early as December to mid-2014. The ruling Liberal Democratic Party and the utilities are keen to get reactors up and running again, with Prime Minister Shinzo Abe singling out reducing soaring fuel costs as a key plank of his economic reform plans.

But opinion polls show a majority of Japanese want to end reliance on atomic power, and oppose re-starts.

"The argument that no nuclear power dents the economy would be myopic, considering that if by mistake we had another tragedy like Fukushima, Japan would suffer from further collateral damage and lose global trust," said Tetsunari Iida, head of the Institute for Sustainable Energy Policies, and a renewable energy expert.

"In the new economy, the less you use energy, the more value-added you become. The big chorus for nuclear power is hampering the efforts to move to a new, more open economy."

IMPORT BILL

Japan consumes about a third of the world's liquefied natural gas (LNG) production, and will likely boost LNG demand to record levels over the next couple of years. LNG imports rose 4.4 percent in volume to a record 86.87 million tonnes, and 14.9 percent in value to a record 6.21 trillion yen ($62.1 billion) in the year through March.

Imports are likely to rise to around 88 million tonnes this year and around 90 million tonnes in the year to March 2015, according to projections by the Institute of Energy Economics Japan based on a mid-scenario that 16 reactors will be back on-line by March 2015.

Thirty months on from the Fukushima disaster, such is the level of public concern about nuclear safety that the government is struggling to come up with a long-term energy policy - a delay that is having a profound impact on the economy and underlining just how costly a nuclear-power-free future may be.

People in the industry reckon Shikoku Electric Power's Ikata plant, Kyushu Electric's Sendai plant and Hokkaido Electric's Tomari plant are among those likely to be the first to re-start.

"There's talk the Abe administration is putting heavy pressure on the regulator (to re-start reactors)," said Osamu Fujisawa, a Japan-based independent oil economist.

"It's obviously the economy the administration is after (rather than safety). Otherwise, the business community will look away, dealing an end to the Abe administration."

(Editing by Ian Geoghegan)


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